GUT 1999;44:143-147 ( February )

Leading article

Role of nitric oxide in intestinal water and electrolyte transport

The first 150 words of the full text of this article appear below.

	Introduction

Since Palmer et al and Ignarro et al showed that vascular endothelial cells could synthesise nitric oxide (NO), this soluble gas has emerged as an important mediator, messenger and regulator of cell function in a number of physiological systems and pathophysiological states.^1-4 The effect of NO on the intestinal epithelium, the local microcirculation, the enteric nervous system, and inflammatory cascades has implicated it as a potential mediator of intestinal water and electrolyte transport.⁵ Data produced by different groups over the past few years have been contradictory, some showing NO as an absorbagogue and others as a secretagogue.

	Biology of nitric oxide and its source in the intestine

In biological systems, NO has a half life of less than 5 seconds, rapidly degrading to nitrite and nitrate in the presence of oxygen and water.¹ Being soluble in both water and lipid, it freely traverses cell membranes and passes into adjacent target cells.⁶ The potential sources of NO in the gut are the . . . [Full text of this article]

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