Commentary
See article on page 246
Endothelins, pseudo-obstruction and Hirschsprung's disease
| The first 150 words of the full text of this article appear below. |
It has been known since the 1950s that the enteric nervous
system is formed from cells that arise from the neural
crest.1 The enteric neurones mainly arise from the vagal
neural crest of the developing hind brain and colonise the gut in a
rostro caudal migration but some seem to arrive in the hind gut from the lumbosacral level via a caudo rostral wave of colonisation. The
neural crest cells that migrate and colonise the gut are committed to
become neuroblasts or neuronal support cells, glioblasts; however, differentiation into neurones and glial cells seems not to take place
until they have reached their final resting places in the gut. Movement
through the gut mesenchyme, survival in the gut and differentiation
into mature cells is strongly influenced by contacts with the
microenvironment which consists of other cells in the mesenchyme,
neural crest, and the extracellular matrix. The extracellular matrix
components provide
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