Commentary
See article on page 168
Cross-reacting antibodies in coeliac disease?
| The first 150 words of the full text of this article appear below. |
Most patients with coeliac disease have antibodies to wheat
gliadin, reticulin, and endomysium. In 1997 a seminal paper showed that
at least a substantial fraction of anti-endomysial antibodies (EMA)
recognises the endogenous enzyme tissue transglutaminase (tTG).1 However, antibodies recognising other antigens can also be found and in this issue (see page 168) Krupi
ková and colleagues attempt to characterise these antibodies.
Anti-gliadin antibodies (AGA) were isolated from coeliac serum samples
using (semi)purified 
-gliadin as the substrate. These antibodies
were tested for specificity using a synthetic -gliadin peptide
competition assay. This important study is the first of its kind. An
interesting finding is that the antibody responses are directed towards
a limited set of epitopes. These epitopes do not overlap with peptides
recognised by small intestinal HLA-DQ restricted T
cells,2 3
but our current knowledge is too limited to
judge whether this is important. One of the epitopes was the VLPVQQQQF
peptide, which
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- Identification of common epitopes on gliadin, enterocytes, and calreticulin recognised by antigliadin antibodies of patients with coeliac disease
- S Krupicková, L Tucková, Z Flegelová, M Michalak, J R F Walters, A Whelan, J Harries, J Vencovský, and H Tlaskalová-Hogenová
Gut 1999 44: 168-173.[Abstract] [Full Text] [PDF]
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