Science alert
Gastric leptin
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Comment
Leptin, a 167 amino acid protein transcribed from the
ob gene, was originally described as a
hormone secreted specifically by adipocytes, that is involved in the
central regulation of food intake and energy expenditure.1
Circulating concentrations of leptin show a strong positive correlation
with fat mass. Leptin acts on the hypothalamus of the brain to regulate
body weight by decreasing food intake and increasing physical activity
and energy expenditure.2 The
ob/ob mouse has a recessive mutation of the
ob gene which results in absence of
circulating leptin leading to hyperphagia, reduced energy expenditure
and development of obesity. Subsequent work has shown that leptin, in
addition to its role in metabolic control, has important roles in
reproduction and neuroendocrine signalling. Both animals and humans
with leptin deficiency have increased circulating corticosterone
concentrations, reduced thyroxine concentrations, and infertility due
to hypogonadotrophic hypogonadism.3 4 In the
ob/ob mouse these changes are reversed by
administration
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This article has been cited by other articles:
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Cammisotto, P. G., Renaud, C., Gingras, D., Delvin, E., Levy, E., Bendayan, M.
(2005). Endocrine and Exocrine Secretion of Leptin by the Gastric Mucosa. J. Histochem. Cytochem.
53: 851-860
[Abstract] [Full Text] -
Mix, H, Widjaja, A, Jandl, O, Cornberg, M, Kaul, A, Goke, M, Beil, W, Kuske, M, Brabant, G, Manns, M P, Wagner, S
(2000). Expression of leptin and leptin receptor isoforms in the human stomach. Gut
47: 481-486
[Abstract] [Full Text]
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