Clinical alert
Total parenteral nutrition with glutamine dipeptide shortened hospital stays and improved immune status and nitrogen economy after major abdominal surgery
| The first 150 words of the full text of this article appear below. |
Question
Is total parenteral nutrition with glutamine dipeptide after major
abdominal surgery effective for improving patients' nitrogen economy
and immune status and for shortening the length of hospital stay?
Design
6 day randomised, double blind, controlled trial.
Setting
Hospital in Germany.
Patients
28 patients (mean age 68 y, 57% women) who were 42 to 86 years of
age and were admitted for elective resection of carcinoma of the colon
or rectum. Exclusion criteria were evident metabolic diseases, or
chronic renal or liver diseases.
Intervention
All patients received 5 days of continuous total parenteral
nutrition containing nitrogen (TPN), 0.24 g/kg/day (isonitrogenous) and
122 kJ/kg/day (isoenergetic). TPN was supplemented by either amino
acids, 1.2 g/kg day, plus the glutamine dipeptide l-alanyl-L-glutamine (Ala-Gln), 0.3 g/kg/day (n=15), or amino acids, 1.5 g/kg/day (n=13). TPN was given through a central venous catheter.
Main outcome measures
Length of stay in hospital, nitrogen balance on days 2-5
after the operation, and immune status (lymphocyte count) on
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