Leading article
Towards immunotherapy of pancreatic cancer
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A recent review of pancreatic carcinoma stated, "In spite of poor results, we must continue to search actively for more accurate methods of diagnosis and better methods of treatment"1; in light of this, further study of immunotherapy may be appropriate.
Gut readers will not be surprised
to see this article as, every decade, immunotherapy becomes a "hot"
topic and, as such, generates short lived enthusiasm. Thus, BCG, tumour
lysates, and even interleukin (IL) 2 as a single agent, have recently
been of interest to those involved in scientific research.
Immunotherapy is currently at the fore as we can now, actively or
passively, stimulate the immune system of patients with pancreatic
cancer, creating an immunotherapeutic regimen which may be partially or completely effective in curing the disease. Why such optimism? Recently, developments in genetic engineering techniques have lead to
breakthroughs identifying tumour antigens, the description of numerous
cytokines (approximately 25, including IL
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This article has been cited by other articles:
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Brett, B. T., Smith, S. C., Bouvier, C. V., Michaeli, D., Hochhauser, D., Davidson, B. R., Kurzawinski, T. R., Watkinson, A. F., Van Someren, N., Pounder, R. E., Caplin, M. E.
(2002). Phase II Study of Anti-Gastrin-17 Antibodies, Raised to G17DT, in Advanced Pancreatic Cancer. JCO
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[Abstract] [Full Text] -
Ito, M., Shichijo, S., Tsuda, N., Ochi, M., Harashima, N., Saito, N., Itoh, K.
(2001). Molecular Basis of T Cell-mediated Recognition of Pancreatic Cancer Cells. Cancer Res.
61: 2038-2046
[Abstract] [Full Text]
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