Commentary
See article on page 867Barrett's oesophagus and colorectal neoplasia: scope for screening?
| The first 150 words of the full text of this article appear below. |
Several studies have reported significant positive associations
between colorectal cancer (CRC) and Barrett's
oesophagus.1-5 In the initial report, 29 colon tumours,
10 of them malignant, were found in 65 patients with Barrett's
oesophagus.1 The authors suggested that the probability of
detecting a similar number of malignant colorectal lesions in an age
matched sample of the general population was less than one in a
million. The early studies, however, were often hampered by their
choice of a "control" group or the complete absence of one. Bias
may also have arisen from the discovery of Barrett's oesophagus during
the investigation of patients with gastrointestinal symptoms referable
to their presentation of a CRC. In addition, the existence of
asymptomatic but prevalent cases of both colon cancer and of Barrett's
oesophagus is now more widely recognised than it was a decade
ago.6 Despite reservations about the validity of these
studies, the finding that colon tumours seemed to
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