Commentary
ANCAs away
| The first 150 words of the full text of this article appear below. |
Significant titres of circulating antibodies reacting with a
wide range of normal tissue components occur with variable frequency in
several liver disorders. Those that are of particular relevance to
liver disease include the antinuclear (ANA), smooth muscle (SMA),
liver-kidney microsomal (LKM), antimitochondrial (AMA), and
antineutrophil cytoplasmic (ANCA) antibodies. In some conditions, such
as autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC), they
form part of the diagnostic criteria.1 2 Their presence
in others, such as chronic viral hepatitis, may serve to confuse. These
autoantibodies are routinely detected by indirect immunofluorescence on sections of appropriate tissues or isolated cells and an experienced eye is required for interpretation of the
different patterns of immunofluorescent staining. It has long been
recognised, however, that antibodies giving apparently similar staining
patterns often react with different antigens in the substrates used for
their detection. In order to improve the sensitivity and specificity of
these antibodies for different
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