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Aggressive mucosa associated lymphoid tissue lymphomas are associated with mutations in Bcl10
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Low grade B cell lymphomas of mucosa associated lymphoid
tissue (MALT) are tumours with characteristically indolent behaviour. They have relatively low proliferation index, benign cellular morphology and histology, and the tumour cells are often interspersed among chronic inflammatory cells.1 Some cases of low grade gastric MALT lymphoma are dependent on local infection with
Helicobacter pylori, compounding their image
as very low grade malignancies.2 The advent of sensitive
polymerase chain reaction methods however showed that these are indeed
tumours which can advance, both in stage, and from low to high
grade.3 Within this group of relatively non-threatening
tumours, there are some clinically aggressive ones. Cells from some of
these tumours proliferate spontaneously in tissue culture and have a
chromosomal translocation between chromosome 1 and the immunoglobulin
heavy chain locus on chromosome 14 (t(1;14)(p22;q32)).4-6
Tumours without the translocation die in culture. Willis
et al have identified and described the
properties of a
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