Gut 1999;45:1-4 ( July )

Leading article

See paper by Ponz de Leon et al, p 32

Microsatellite instability

The first 150 words of the full text of this article appear below.

	Biology

GENETIC INSTABILITY IN TUMOURS
Genetic perturbation has been implicated in the development of tumours since the turn of the century. Indeed, genetic instability of one sort or another may be considered to be a hallmark of cancer itself, and the discovery of microsatellite instability (MSI) made it evident that there was more than one mechanism underlying this process. ^1 2 As with most new discoveries, there was an initial flurry of excitement with raised hopes and exaggerated claims, followed by the realisation that MSI was not as simple, easy, or likely to give results as had first been thought. The understanding of MSI and its potential clinical utility has continued to develop, but it is only now that its real usefulness is becoming apparent.

MICROSATELLITE INSTABILITY: DID IT FALL OR WAS IT PUSHED?
DNA synthesis is liable to errors, either as part of DNA replication before cell division, or as part of . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Hereditary colorectal cancer in the general population: from cancer registration to molecular diagnosis

M Ponz de Leon, M Pedroni, P Benatti, A Percesepe, C Di Gregorio, M Foroni, G Rossi, M Genuardi, G Neri, F Leonardi, A Viel, E Capozzi, M Boiocchi, and L Roncucci
Gut 1999 45: 32-38. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

• Zagari, R M, Fuccio, L, Wallander, M-A, Johansson, S, Fiocca, R, Casanova, S, Farahmand, B Y, Winchester, C C, Roda, E, Bazzoli, F (2008). Gastro-oesophageal reflux symptoms, oesophagitis and Barrett's oesophagus in the general population: the Loiano-Monghidoro study. Gut 57: 1354-1359 [Abstract] [Full Text]  
• Castillejo, G., Bullo, M., Anguera, A., Escribano, J., Salas-Salvado, J. (2006). A Controlled, Randomized, Double-Blind Trial to Evaluate the Effect of a Supplement of Cocoa Husk That Is Rich in Dietary Fiber on Colonic Transit in Constipated Pediatric Patients. Pediatrics 118: e641-e648 [Abstract] [Full Text]  
• Kamiya, T, Wang, L, Forsythe, P, Goettsche, G, Mao, Y, Wang, Y, Tougas, G, Bienenstock, J (2006). Inhibitory effects of Lactobacillus reuteri on visceral pain induced by colorectal distension in Sprague-Dawley rats. Gut 55: 191-196 [Abstract] [Full Text]  
• Dong, L., Dingguo, L., Xiaoxing, X., Hanming, L. (2005). An Epidemiologic Study of Irritable Bowel Syndrome in Adolescents and Children in China: A School-Based Study. Pediatrics 116: e393-e396 [Abstract] [Full Text]  
• Atkinson, W, Sheldon, T A, Shaath, N, Whorwell, P J (2004). Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut 53: 1459-1464 [Abstract] [Full Text]  
• Joy, D, Scott, B B (2003). To perform or not to perform liver biopsy: an alternative view. Gut 52: 610-610 [Full Text]  
• Gunn, M C, Cavin, A A, Mansfield, J C (2003). Management of irritable bowel syndrome. Postgrad. Med. J. 79: 154-158 [Abstract] [Full Text]  
• Van Outryve, S M, Van Outryve, M J, De Winter, B Y, Pelckmans, P A (2002). Is anorectal endosonography valuable in dyschesia?. Gut 51: 695-700 [Abstract] [Full Text]  
• Frayling, I M (2002). Methods of molecular analysis: mutation detection in solid tumours. Mol. Pathol. 55: 73-79 [Abstract] [Full Text]  
• VASSILAKIS, D. A., SOURVINOS, G., SPANDIDOS, D. A., SIAFAKAS, N. M., BOUROS, D. (2000). Frequent Genetic Alterations at the Microsatellite Level in Cytologic Sputum Samples of Patients with Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 162: 1115-1119 [Abstract] [Full Text]  
• Lu, Z. X., Gibson, P. R., Muir, J. G., Fielding, M., O’Dea, K. (2000). Arabinoxylan Fiber from a By-Product of Wheat Flour Processing Behaves Physiologically like a Soluble, Fermentable Fiber in the Large Bowel of Rats. J. Nutr. 130: 1984-1990 [Abstract] [Full Text]  
• Starodub, A. M., Wood, J. D. (2000). Histamine H2 Receptor Activated Chloride Conductance in Myenteric Neurons From Guinea Pig Small Intestine. J. Neurophysiol. 83: 1809-1816 [Abstract] [Full Text]