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| The first 150 words of the full text of this article appear below. |
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Biology |
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GENETIC INSTABILITY IN TUMOURS
Genetic perturbation has been implicated in the development of
tumours since the turn of the century. Indeed, genetic instability of
one sort or another may be considered to be a hallmark of cancer itself, and the discovery of microsatellite instability (MSI) made
it evident that there was more than one mechanism underlying this
process. 1 2 As with most new discoveries, there was an
initial flurry of excitement with raised hopes and exaggerated claims,
followed by the realisation that MSI was not as simple, easy, or likely
to give results as had first been thought. The understanding of MSI and
its potential clinical utility has continued to develop, but it is only
now that its real usefulness is becoming apparent.
MICROSATELLITE INSTABILITY: DID IT FALL OR WAS IT
PUSHED?
DNA synthesis is liable to errors, either as part of DNA
replication before cell division, or as part of
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