Commentary
See article on page 82Glutamine in parenteral nutrition: more food for thought
| The first 150 words of the full text of this article appear below. |
Until recently glutamine had not been included in
commercial parenteral nutrition solutions. This is because of concerns
about its spontaneous degradation, which results in the formation of pyroglutamic acid and ammonia. However, the degradation rate is slower than previously thought, especially in dextrose containing parenteral nutrition solutions.1 2 Therefore, parenteral nutrition solutions containing free glutamine can be stored at 4°C
for at least a few days before clinical use. The study by Powell-Tuck
et al (see page 82) is one of a handful of
studies that has included free glutamine in parenteral nutrition
solutions. Stable synthetic glutamine containing dipeptides are also
available as an alternative source of glutamine. In considering how
much glutamine should be added to parenteral nutrition solutions it is
useful to refer to the normal dietary intake. Surprisingly, the
quantities of glutamine in normal diets are not accurately known
because food tables usually report glutamine and glutamate
Relevant Article
- A double blind, randomised, controlled trial of glutamine supplementation in parenteral nutrition
- J Powell-Tuck, C P Jamieson, G E A Bettany, O Obeid, H V Fawcett, C Archer, and D L Murphy
Gut 1999 45: 82-88.[Abstract] [Full Text] [PDF]
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