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Hepatitis C and liver transplantation
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Introduction |
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Cirrhosis secondary to hepatitis C virus (HCV) infection, alone or in combination with alcohol, is the principal indication for liver transplantation among adults, and is responsible for about half the transplants performed in many centres.1 2 This may mean that a subset of the approximately 300 million people worldwide infected with HCV will progress to cirrhosis, liver failure, and would need a transplant in the future.3 As there is no universally effective antiviral treatment, it is expected that demand will soon outstrip the already limited donor organ supply.
Some facts about HCV infection and liver transplantation have been
substantiated since the end of 1998. (a) HCV
infection (as defined by detectable viraemia) will occur universally
after liver transplantation among patients who are viraemic before
transplantation4; (b) de novo
HCV infection is rare but may still occur even though blood products
are screened5; (c) HCV related
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