Commentary
See article on page 269Cyclosporin and chronic pancreatitis: a supermodel?
| The first 150 words of the full text of this article appear below. |
Most patients with acute pancreatitis develop their disease in association with either biliary tract stones or abuse of ethanol, whereas chronic pancreatitis is most commonly the result of prolonged ethanol abuse. Attempts to study the pathogenesis and pathophysiology of these inflammatory conditions have been hampered by the relative inaccessibility of the pancreas to study in humans, as well as the difficulty in identifying appropriate patients during the earliest stages of their disease.
Over the past two decades, several models of acute pancreatitis induced in laboratory animals have been developed.1-3 Use of these models has permitted the performance of studies that have advanced our understanding of the early cellular events that underlie the development of acute pancreatitis.4 Unfortunately, similar progress in the area of chronic pancreatitis has not been made, mainly because no good models of that disease have been developed.
The hallmarks of chronic pancreatitis are the combined presence of
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