Science alert
Nuclear factor 
B in liver disease
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The control of gene expression by transcription factors is central
to the development and regulated function of multicellular organisms.
Perhaps the best understood group of transcription factors is the
nuclear factor (NF) 
B family, the members of which, in response to
activation by a range of extracellular factors, regulate the expression
of genes responsible for promoting inflammation and modulating
apoptotic responses. Interested readers may wish to refer to a recent
review on this topic by Neurath et
al.1 NF-B is composed of homodimers and
heterodimers of members of the Rel protein family, the most ubiquitous
being p65/RelA which typically heterodimerises with p50 to form active
transcription factor complexes. It is not surprising that NF-B
activation is tightly regulated via a cascade of kinase reactions
mediated by a multiprotein complex. The key event after stimulation
(usually by the binding of cytokines such as tumour necrosis factor
(TNF) 
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