Commentary
See article on page 559Short bowel, short answer?
| The first 150 words of the full text of this article appear below. |
The paper by Jeppsen et al (see page 559) shows that glucagon-like peptide-2 (GLP-2) concentrations are low in patients lacking an ileum and colon. This is not an unexpected finding as the L cells that produce GLP-2 are situated in the ileum and colon. GLP-2 is an enterocyte specific growth hormone that in mice causes small and large bowel villus/crypt growth and increases small and large bowel length and weight. In mice it also reduces body weight loss and restores mucosal integrity after dextran induced colitis. In pigs it reduces gastric antral motility.1 The deficiency of GLP-2 in patients with a jejunostomy may explain why these patients show no evidence of structural or functional intestinal adaptation over time.2-4
A distal ileal/colonic peptide with glucagon-like immunoreactivity has
been recognised for many years and termed enteroglucagon. However, the
molecular structure of enteroglucagon was originally unknown and serum
concentrations were derived by
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Relevant Article
- Impaired meal stimulated glucagon-like peptide 2 response in ileal resected short bowel patients with intestinal failure
- P B Jeppesen, B Hartmann, B S Hansen, J Thulesen, J J Holst, and P B Mortensen
Gut 1999 45: 559-563.[Abstract] [Full Text] [PDF]
This article has been cited by other articles:
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Jeppesen, P. B.
(2003). Clinical Significance of GLP-2 in Short-Bowel Syndrome. J. Nutr.
133: 3721-3724
[Abstract] [Full Text]
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