Leading article
Vaccines against gut pathogens
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Many infectious agents enter the body using the oral route and
are able to establish infections in or through the gut. For protection
against most pathogens we rely on immunity to prevent or limit
infection. The expression of protective immunity in the gut is normally
dependent both on local (mucosal) and systemic mechanisms. In order to
obtain full protection against some pathogens, particularly
non-invasive micro-organisms such as Vibrio
cholerae, mucosal immunity may be particularly important. There
is a need to take these factors into account when designing vaccines
targeting gut pathogens. Conventional parenteral vaccines (injected
vaccines) can induce a degree of systemic immunity but are generally
poor stimulators of mucosal responses. Thus, a basic prerequisite for designing novel vaccines against gut associated pathogens may be the
requirement to induce mucosal and potentially systemic immunity.1 The most effective way to induce local immunity against infectious agents has so far proved to
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This article has been cited by other articles:
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Dougan, G., Huett, A., Clare, S.
(2002). Vaccines against human enteric bacterial pathogens. Br Med Bull
62: 113-123
[Abstract] [Full Text] -
Villarreal-Ramos, B., Manser, J. M., Collins, R. A., Chance, V., Eckersall, D., Jones, P. W., Dougan, G.
(2000). Susceptibility of calves to challenge with Salmonella typhimurium 4/74 and derivatives harbouring mutations in htrA or purE. Microbiology
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[Abstract] [Full Text]
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