Commentary
See article on page 730COX-2 in large bowel cancer: a one-sided story
| The first 150 words of the full text of this article appear below. |
Colorectal cancer is the third most common cancer and the
second most common cause of death from cancer in many industrialised countries. This disease will affect 5% of the US population, resulting in over 130 000 new cases and 57 000 deaths projected this year. The
age adjusted death rates are highly variable in populations located in
different parts of the world. For example, there are 3.4 cases per
100 000 in Nigeria compared with 35.8 cases per 100 000 each year in
the state of Connecticut, USA. This indicates that, apart from the
known genetic factors, certain environmental and dietary factors are
probably involved in the aetiology of this disease. Epidemiological,
clinical and genetic evidence indicates that a great number of
colorectal adenocarcinomas develop from a benign adenomatous polyp
progressing through a sequence of events which may take about 15-20
years.1 The progression of events leading to
transformation of colonic epithelial cells includes a series
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Gut 1999 45: 730-732.[Abstract] [Full Text] [PDF]
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