Clinical alert
Treatment of fistulas in Crohn's disease with infliximab
Present DH,
Rutgeerts P,
Targan S,
et al. Infliximab for the treatment of fistulas in patients with Crohn's disease.
N Engl J Med
1999;340:1938-1405
The first 150 words of the full text of this article appear below.
In patients with
Crohn's disease and draining fistulas will treatment with infliximab,
monoclonal antibody to tumour necrosis factor 
, result in fistula closure?
Randomised, double blind, controlled trial with 18 weeks' follow up.
Setting12 centres in the United States (n=7), the UK (n=2), the Netherlands (n=2), and Belgium (n=1).
Patients94 Crohn's disease patients aged 18-65 years with single or multiple fistulas (90% perianal, 55% multiple) were randomised. Patients on stable doses of azathioprine/mercaptopurine (40%), corticosteroids (35%) and aminosalicylates (55%) were included but patients on cyclosporin or with other complications such as abscesses or strictures were excluded.
InterventionPatients were allocated to either infliximab 5 mg/kg (n=31), infliximab 10 mg/kg (n=32) or placebo (n=31) given as a two hour intravenous infusion at weeks 0, 2 and 6.
Main outcome measuresThe
primary end point was a 50% or greater reduction in the number of
draining fistulas at two or more consecutive assessments
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This article has been cited by other articles:
-
Conroy, C A, Cattell, R
(2001). Infliximab treatment for Crohn's disease. Postgrad. Med. J.
77: 436-440
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