Commentary
See article on page 270DMT1 expression: avoiding too much of a good thing
| The first 150 words of the full text of this article appear below. |
Haemochromatosis is a common, inherited disorder of iron
metabolism. The gene (HFE), which is mutated
in the majority of patients, has been cloned. The HFE protein, however,
is not an iron transporter, but rather is thought to function as a
regulator of iron absorption. The cloning of the
HFE gene was followed rapidly by the
identification of further proteins involved in the iron absorption
pathway in the duodenum and transfer to the main iron storage site in
the liver. The identification of a new metal ion transporter in the rat
provided the first molecular information on the active absorption of
metal ions by mammalian cells.1 This divalent metal
transporter 1 (DMT1) has a broad substrate specificity that includes
Fe2+ and a range of other divalent metal
cations.1 (DMT1 is also referred to as divalent cation
transporter 1, DCT1, and natural resistance-associated macrophage
protein 2, Nramp2.) DMT1 mRNA is widely expressed, with
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- Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload
- D Trinder, P S Oates, C Thomas, J Sadleir, and E H Morgan
Gut 2000 46: 270-276.[Abstract] [Full Text] [PDF]
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