Commentary
See article on page 283Fibrosing colonopathy
| The first 150 words of the full text of this article appear below. |
Healing by fibrosis represents the end stage of a response to a variety of insults. Known antecedents to fibrosis in the colon include ischaemia, inflammation (e.g., Crohn's colitis), and noxious chemicals (e.g., irritant laxatives). Endogenous pancreatic enzymes may have a role in enhancing, even if not initiating, lesions which lead to fibrosis, as shown by animal experiments in which ligation of the pancreatic duct mitigated or delayed the response to ischaemia.1
It has been recognised fairly recently that a distinctive form of
fibrosing colonopathy develops in young children with cystic fibrosis
taking mega-doses of pancreatic enzymes, and it was suggested that the
enzyme preparations themselves may be the cause.2 The most
striking feature is a thick band of submucosal fibrosis, suggesting
that some component of the enzyme preparation must gain access through
the mucosal barrier, but evidence of healed mucosal ulceration has only
been observed in a few cases. Vascular
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Article
- Fibrosing colonopathy in an adult owing to over use of pancreatic enzyme supplements
- D S Bansi, A Price, C Russell, and M Sarner
Gut 2000 46: 283-285.[Abstract] [Full Text] [PDF]
This article has been cited by other articles:
-
HAUSLER, M, HEIMANN, G, MEILICKE, R, BIESTERFELD, S
(2000). Coeliac disease and unfavourable outcome of pregnancy.. Gut
47: 598-598
[Full Text]
- Full Text
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
