Science alert
Prostaglandins and the induction of food sensitive enteropathy
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The role of antigen specific T lymphocytes in mediating food sensitive enteropathies such as coeliac disease has been suggested for many years,1 but the link between specific T cell activation and intestinal pathology has been difficult to prove directly. This partly reflects the absence of suitable animal models in which mucosal T cells can be activated by dietary antigens, owing to the fact that immunological tolerance is the usual result of feeding dietary protein antigens to animals.2 3 Therefore the recent paper by Newberry et al describing the induction of small bowel enteropathy in mice fed hen egg lysozyme (HEL) as a representative dietary protein, is a welcome and interesting addition to the field.
Activation of mucosal CD4+ T cells by alloantigens during a
graft-versus-host reaction (GvHR) in experimental
mice,4 5 or by mitogens in explants of human fetal
intestine in vitro6 7 can produce a pattern of small
bowel pathology similar
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