Leading article
Is liver fibrosis reversible?
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Liver fibrosis and cirrhosis result from the majority of
chronic liver insults and represent a common and difficult clinical challenge of worldwide importance. At present, the only curative treatment for end stage cirrhosis is transplantation, but even in the
developed world, the number of donor organs available and the clinical
condition of the potential recipient limit the applicability of this
technique. The alternative clinical course is one familiar to
gastroenterologists
that of a progressive damage limitation exercise
in which the complications of fibrosis and cirrhosis are treated with
greater or lesser success. The development of fibrosis, and
particularly cirrhosis, is associated with a significant morbidity and
mortality. Thus, there is a considerable imperative to develop
antifibrotic strategies that are applicable to liver fibrosis. Such an
approach is attractive precisely because it is aimed at the final
common pathological pathway of chronic liver disease, regardless of
aetiology. However, because fibrotic liver
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