The intracellular target of butyrate's actions: HDAC or HDON'T?

doi:10.1136/gut.46.4.447

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See articles on pages 493 and 507

The intracellular target of butyrate's actions: HDAC or HDON'T?

The first 150 words of the full text of this article appear below.

Butyrate, the four-carbon short chain fatty acid, has special significance for clinicians and scientists interested in largebowel physiology. It is normally present in the colonic lumenat millimolar concentrations as a product of bacterial fermentationof luminal carbohydrates and is readily taken up by the colonicepithelium to be used as a major energy source via $beta$ -oxidation.Butyrate affects key functions of the colonic epithelium in vivoor at least in vitro in models of the colonic epithelium. Thesefunctions include promotion of sodium and water absorption, improvementof tight junction permeability, and acceleration of epithelialrestitution. Thus, butyrate plays an important role in the maintenanceof colonic mucosalhealth.

Butyrate has also been implicated in the pathogenesis of colonic diseases, especially colorectal cancer and ulcerative colitis.Butyrate's role in the pathogenesis of ulcerative colitis hasbeen a fascinating saga. In 1981, Roediger first reported thatepithelial cells isolated from . . . [Full text of this article]

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