Commentary
See article on page 540Think cytokines before you drink
| The first 150 words of the full text of this article appear below. |
Conditions which arise from single gene defects demonstrate a simple mendelian mode of inheritance. There are however a large number of common conditions in which genetic factors are thought to be involved but are not clearly passed from one individual to another and merely cluster in families. Such observations raise a number of questions including: what is the size of the genetic contribution to the disorder and how might the susceptibility gene(s) involved in the development of the condition be identified ?
The National Academy of Sciences-National Research Council twin
registry of almost 16 000 twin pairs reported concordance rates for
cirrhosis of 16.9% in monozygotic twins and 5.3% in dizygotic twins,
implying a genetic predisposition to this complication of alcohol
abuse.1 Although it is possible that twins share not only
genes but a similar environment, with greater (in utero) environmental
sharing in monozygotic twins, there is increasing epidemiological2 and laboratory3 evidence
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Gut 2000 46: 540-545.[Abstract] [Full Text] [PDF]
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