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Antimicrobial peptides in innate intestinal host defence
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Following two recent review articles,1 2 readers of Gut will be aware of the increasing interest in the role of antimicrobial peptides in innate intestinal host defence.
Antimicrobial peptides of the defensin family were first isolated from
neutrophils and macrophages in the 1980s and the expression of members
of this family (designated cryptdins) in murine Paneth cells was
subsequently reported.3-5 Based on the organisation of
their disulphide bonds, the defensin family has been further subdivided
into 
and 
defensins, with the human neutrophil defensins 1-4
(HNP 1-4) and murine cryptdins falling into the former group. Previous
studies have shown that defensins are synthesised as biologically
inactive precursor molecules that require processing to the mature
peptides that express antimicrobial activity.6 Normal
murine Paneth cells contain mature forms of cryptdin,3-5 implying that the enzyme that cleaves the precursor cryptdin isoforms is also present within Paneth cells. This recent study by Wilson and
colleagues
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This article has been cited by other articles:
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Allaker, R. P., Kapas, S.
(2003). Adrenomedullin Expression by Gastric Epithelial Cells in Response to Infection. CVI
10: 546-551
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