Commentary
See article on page 473No H pylori: less dyspepsia?
| The first 150 words of the full text of this article appear below. |
Functional dyspepsia is a common disorder of heterogeneous aetiology for which there is no clearly effective treatment. In this issue of Gut, Blum and colleagues1 report their large controlled clinical trial assessing the effectiveness of antisecretory medication in functional dyspepsia (see page 473). Patients with and without evidence of Helicobacter pylori infection were recruited into the study.
The study found symptomatic benefit over placebo at the end of two
weeks' treatment with omeprazole 20 mg per day in
H pylori positive patients but no
significant benefit in primary outcome with the same treatment in
H pylori negative patients. The therapeutic gain over placebo for omeprazole 20 mg in the H
pylori positive patients was 17.6% (95% confidence intervals
4.2-31%; p<0.014). There was no significant benefit over placebo
following omeprazole 10 mg or ranitidine 150 mg in
H pylori positive patients or following any
of the three treatments in the H pylori
negative
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Gut 2000 47: 473-480.[Abstract] [Full Text] [PDF]
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