Science alert
Specific targeting of IL-6 signalling pathway: a new way to treat IBD?
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More than 200 cytokines have been identified that bind to specific receptors expressed on the surface of the target cells. They are able to trigger intracellular signalling cascades leading to the control of gene expression involved in the cellular response. Although a lot of detailed information on the signalling cascade and effects of specific cytokines on various cells has accumulated over the past few years, our understanding of cytokine functions in vivo remains very poor.
These uncertainties are particularly illustrated by the case of
interleukin (IL)-6. The in vivo functions of this cytokine remain
debated, IL-6 being considered alternatively as a pro- or
anti-inflammatory cytokine,1 2 or sometimes as a key
factor to polarise Th2 cells.3 Moreover, the IL-6
signalling is particular involving a phenomenon called
trans signalling.4 Briefly, the receptor for IL-6 consists of two subunits: a ligand binding
component (IL-6R) and a signal-transducing glycoprotein 130 (gp130)
which is a member
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