|
|
||||||||||||||
|
|
|||||||||||||||
| The first 150 words of the full text of this article appear below. |
| |
Introduction |
|---|
The luminal surface of the gastrointestinal tract is covered by a viscoelastic mucous gel layer that acts as a protective barrier against the harsh luminal environment. The structural characteristics of this barrier are primary indicators of its physiological function and changes to its composition have long been identified in gastrointestinal pathologies. During the past decade significant improvements in analytical techniques coupled with detailed knowledge of the genes coding for the mucin proteins have provided exciting new insights into the role of the mucous layer and its relevance to gastrointestinal disease.
The high molecular weight mucins are responsible for the viscoelastic
properties of the mucous barrier. They are widely expressed in
epithelial tissues and are characterised by variable number tandem
repeat peptide sequences rich in serine, threonine, and proline which
carry large numbers of O-linked
oligosaccharide chains.1 2 At present, 12 genes have been
described, shown in table 1.1 3 Secreted and
This article has been cited by other articles:
![]() |
A. Swidsinski, V. Loening-Baucke, F. Theissig, H. Engelhardt, S. Bengmark, S. Koch, H. Lochs, and Y. Dorffel Comparative study of the intestinal mucus barrier in normal and inflamed colon Gut, March 1, 2007; 56(3): 343 - 350. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Faure, C. Mettraux, D. Moennoz, J.-P. Godin, J. Vuichoud, F. Rochat, D. Breuille, C. Obled, and I. Corthesy-Theulaz Specific Amino Acids Increase Mucin Synthesis and Microbiota in Dextran Sulfate Sodium-Treated Rats J. Nutr., June 1, 2006; 136(6): 1558 - 1564. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Lievin-Le Moal and A. L. Servin The Front Line of Enteric Host Defense against Unwelcome Intrusion of Harmful Microorganisms: Mucins, Antimicrobial Peptides, and Microbiota Clin. Microbiol. Rev., April 1, 2006; 19(2): 315 - 337. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. C. Rose and J. A. Voynow Respiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease Physiol Rev, January 1, 2006; 86(1): 245 - 278. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Faure, D. Moennoz, F. Montigon, C. Mettraux, D. Breuille, and O. Ballevre Dietary Threonine Restriction Specifically Reduces Intestinal Mucin Synthesis in Rats J. Nutr., March 1, 2005; 135(3): 486 - 491. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Allen and G. Flemstrom Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin Am J Physiol Cell Physiol, January 1, 2005; 288(1): C1 - C19. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Gaudier, A. Jarry, H. M. Blottiere, P. de Coppet, M. P. Buisine, J. P. Aubert, C. Laboisse, C. Cherbut, and C. Hoebler Butyrate specifically modulates MUC gene expression in intestinal epithelial goblet cells deprived of glucose Am J Physiol Gastrointest Liver Physiol, December 1, 2004; 287(6): G1168 - G1174. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Goso, T. Ikezawa, M. Kurihara, M. Endo, K. Hotta, and K. Ishihara Characterization of Rat Gastric Mucins Using a Monoclonal Antibody, RGM23, Recognizing Surface Mucous Cell-Type Mucins J. Biochem., April 1, 2003; 133(4): 453 - 460. [Abstract] [Full Text] [PDF] |
||||
![]() |
P A Sylvester, M Walsh, N Myerscough, B F Warren, A P Corfield, M G Thomas, and P Durdey Mucin gene expression in the ileoanal reservoir is altered and may be relevant to the risk of inflammation and dysplasia Gut, September 1, 2002; 51(3): 386 - 391. [Abstract] [Full Text] |
||||
![]() |
M. Perrais, P. Pigny, M.-C. Copin, J.-P. Aubert, and I. Van Seuningen Induction of MUC2 and MUC5AC Mucins by Factors of the Epidermal Growth Factor (EGF) Family Is Mediated by EGF Receptor/Ras/Raf/Extracellular Signal-regulated Kinase Cascade and Sp1* J. Biol. Chem., August 23, 2002; 277(35): 32258 - 32267. [Abstract] [Full Text] [PDF] |
||||
![]() |
K Kobayashi, H Ogata, M Morikawa, S Iijima, N Harada, T Yoshida, W R Brown, N Inoue, Y Hamada, H Ishii, et al. Distribution and partial characterisation of IgG Fc binding protein in various mucin producing cells and body fluids Gut, August 1, 2002; 51(2): 169 - 176. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Mollenhauer, S. Herbertz, B. Helmke, G. Kollender, I. Krebs, J. Madsen, U. Holmskov, K. Sorger, L. Schmitt, S. Wiemann, et al. Deleted in Malignant Brain Tumors 1 Is a Versatile Mucin-like Molecule Likely to Play a Differential Role in Digestive Tract Cancer Cancer Res., December 1, 2001; 61(24): 8880 - 8886. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |