Commentary
See article on page 787Genetics of inflammatory bowel disease: a puzzle with contradictions?
| The first 150 words of the full text of this article appear below. |
Genetic factors have a well established role in the aetiology of inflammatory bowel disease (IBD). The mode of inheritance suggests a polygenic disease with penetrance of the genetic factors being strongly influenced by the lifestyle of an industrialised society. The development of linkage analysis has allowed the generation of important molecular clues to the location of putative disease genes.1
The inheritance of genomic DNA can be traced by identification of highly polymorphic regions ("microsatellites"). Ideally, polymorphic regions should be used which are present in a high number of variations ("alleles") in the population (that is, are highly informative).
If a phenotype (for example, disease) is inherited, the use of linkage
analysis assumes that it will be possible to trace the piece of DNA
which contains the putative disease gene. In affected relative pairs of
individuals (sharing the same phenotype), certain areas of the DNA
which contain disease genes should therefore
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