Commentary
See article on page 820Gastrin, growth, and colon neoplasia
| The first 150 words of the full text of this article appear below. |
The ability of the gastric hormone gastrin to stimulate gut
epithelial cell proliferation has been appreciated since the late 1960s.1 However, aside from the special case of gastric
carcinoid tumours arising from enterochromaffin-like cells, the
contribution of gastrin to gastrointestinal neoplasia has been
uncertain. Several developments now suggest a role for gastrin in both
gastric and colorectal cancer. In the case of gastric cancer, recent
evidence indicates a synergy between gastrin and
Helicobacter infection in accelerating
progression to atrophy and cancer.2 Different issues are
involved in colorectal cancer. The important emerging concepts here are
that (a) the gastrin gene is expressed in colorectal cancer cells, but
(b) the main products of gene expression in these cells are not ligands
for the gastrin-cholesystokinin receptor B (CCKB), although (c) they do
act as colon growth factors. The paper by Smith and
Watson3 now shows that gastrin mRNA, detected by reverse
transcription-polymerase chain
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Relevant Article
- Gastrin and gastrin receptor activation: an early event in the adenoma-carcinoma sequence
- A M Smith and S A Watson
Gut 2000 47: 820-824.[Abstract] [Full Text] [PDF]
This article has been cited by other articles:
-
Schulz, S., Rocken, C., Mawrin, C., Schulz, S.
(2005). Immunohistochemical Localization of CCK1 Cholecystokinin Receptors in Normal and Neoplastic Human Tissues. J. Clin. Endocrinol. Metab.
90: 6149-6155
[Abstract] [Full Text] -
Reubi, J. C.
(2003). Peptide Receptors as Molecular Targets for Cancer Diagnosis and Therapy. Endocr. Rev.
24: 389-427
[Abstract] [Full Text] -
Stubbs, M., Khan, K., Watson, S. A., Savage, K., Dhillon, A. P., Caplin, M. E.
(2002). Endocytosis of Anti-CCK-B/Gastrin Receptor Antibody and Effect on Hepatoma Cell Lines. J. Histochem. Cytochem.
50: 1213-1217
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
