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Inherited predisposition to pancreatic cancer
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Introduction |
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Pancreatic cancer is the fifth leading cause of death from cancer in men and women in Europe and North America. The prognosis has not changed significantly despite improvements in diagnosis and perioperative management. Traditional chemotherapy and radiotherapy regimens have been rather ineffective in providing control of the disease.1
The only consistent risk factor identified so far is smoking and
possibly accounts for a quarter of all cases of pancreatic cancer.2 Diabetes mellitus is another factor associated
with an increased risk for the development of pancreatic cancer
although it is still unclear if diabetes is a cause or an effect of
malignant disease in the organ.3 Surgical resection offers
the best chance of prolongation in survival. Unfortunately, in
more than 80% of cases, at the time of diagnosis the cancer is either
locally advanced or disseminated thus excluding curative resection.
Hope for making an appreciable impact on survival has been focused
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