Commentary
See article on page 297Helicobacter pylori associated gastric B cell MALT lymphoma: predictive factors for regression
| The first 150 words of the full text of this article appear below. |
Experimental data have extended the knowledge of the mere
association of gastric mucosa associated lymphoid tissue (MALT) lymphoma and infection with Helicobacter pylori.
The acquisition of MALT in the stomach is a direct consequence
of the infection; thus MALT in the stomach is formed as an
immunological defence system to control local infection caused by
H pylori. Lymphomas arising from gastric
MALT show several specific features: they arise from the marginal zone
of the lymphoid follicle, they consist of centrocyte-like cells, and
lymphoepithelial destruction must be present in order to establish the
diagnosis of gastric MALT lymphoma.1 2 The genetic events
that lead to clonal evolution and, finally, malignant transformation
also show that MALT lymphomas have specific features not known from
nodal lymphomas
for example, the translocation t(11;18). Data
concerning other genetic events like rearrangements of oncogenes such
as bcl-2 (translocation t(14;18) in
follicular lymphoma), c-my (translocation
t(8;14) in Burkitt's lymphoma),
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- Predictive factors for regression of gastric MALT lymphoma after anti-Helicobacter pylori treatment
- A Ruskoné-Fourmestraux, A Lavergne, P H Aegerter, F Megraud, L Palazzo, A de Mascarel, T Molina, and J-C L Rambaud
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