Gut 2001;48:743-747 ( June )

Leading article

The importance of interleukin 1 in Helicobacter pylori associated disease

The first 150 words of the full text of this article appear below.

	Introduction

Helicobacter pylori infection is associated with divergent clinical outcomes that range from simple asymptomatic gastritis to more serious conditions such as peptic ulcer disease and gastric neoplasia. The key determinants of these outcomes are the severity and distribution of the H pylori induced gastritis. Gastritis that is largely confined to the antral region is associated with excessive acid secretion and a high risk of duodenal ulcer disease.¹ In contrast, gastritis that involves the acid secreting corpus region leads to hypochlorhydria, progressive gastric atrophy, and an increased risk of gastric cancer.² The association of H pylori with such variable outcome poses a fascinating scientific challenge, the unravelling of which will not only explain how ulcers and gastric cancer develop but will also act as a paradigm for gene-environment interactions in most human diseases. The proinflammatory cytokine interleukin (IL)-1 is emerging as a key mediator of many pathophysiological events that characterise . . . [Full text of this article]

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