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Detection of persistent measles virus infection in Crohn's disease: current status of experimental work
| The first 150 words of the full text of this article appear below. |
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Introduction |
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The aetiology of Crohn's disease is unknown. Any hypothesis
must take into account the continuing increase in incidence in some
countries, including the UK. The increase affects the population from
early teens, and specific comprehensive epidemiological studies in
children and adolescents show a continuing rise in the rate of age and
sex standardised incidence in Scotland.1 This suggests an
environmental trigger, which may interact with underlying genetic susceptibility. A number of such environmental triggers have been proposed, including persistent infections, transient infections in a
host with abnormal mucosal immunity, particulate materials, or dietary
changes. Persistent infection with the measles virus after wild-type
virus infections or immunisation with live attenuated measles vaccine
have been proposed as important environmental triggers based on
epidemiological observations.2 3 Measles is a single
stranded RNA virus which can induce immune suppression. Measles
infection is generally self limited and results in long term immunity,
but rarely, persistent infection
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