Therapy update
Liquid diets for Crohn's disease
| The first 150 words of the full text of this article appear below. |
In the early 1970s, disease modifying effects of an elemental diet
in Crohn's disease (CD) were observed. The first controlled study in
1984 confirmed that an elemental diet was as effective as steroids in
inducing remission in acute CD.1 Several subsequent studies supported this primary therapeutic effect for both elemental and polymeric enteral diets (see review2). Pooling the
data however has shown a less favourable outcome with three
meta-analyses similarly concluding that corticosteroids were more
effective than enteral diet therapy. A heterogeneous study mix may not
be representative of the clinical situation. Data, from a single centre
spanning 10 years of enteral diet therapy supported remission rates
equal to that of drug therapy.3 In addition to therapeutic effect, liquid diets for acute CD offer an unrivalled safety profile and significant nutritional benefits. We consider these diets as ideal
therapy in paediatric CD, especially in the presence
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Stoll, B., Price, P. T., Reeds, P. J., Chang, X., Henry, J. F., van Goudoever, J. B., Holst, J. J., Burrin, D. G.
(2006). Feeding an Elemental Diet vs a Milk-Based Formula Does Not Decrease Intestinal Mucosal Growth in Infant Pigs. JPEN J Parenter Enteral Nutr
30: 32-39
[Abstract] [Full Text]
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