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What comes after macrolides and other motilin stimulants?
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Delayed gastric emptying is often considered the major pathophysiological mechanism underlying symptoms in both functional dyspepsia and diabetic gastroparesis. Studies have reported a significant delay in the gastric emptying rate of solids in up to 50% of patients with functional dyspepsia and in up to 75% of patients with type 1 diabetes.1 2 Prokinetic agents, including metoclopramide, domperidone, and cisapride, have traditionally been used to enhance gastric emptying rate and to improve symptoms in these patients. However, their prokinetic effect was moderate and the symptomatic response was often poor.1
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Development of motilides |
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In view of the limited options to treat these patients, the report
of the strong gastrokinetic effect of erythromycin3 was
met with great enthusiasm. This surprising effect of erythromycin relates to its ability to act as a motilin receptor
agonist,4 and several motilides (motilin agonists) lacking
antibiotic activity were developed, including ABT-229. However, the
outcomes of clinical trials with ABT-229 were unequivocally
disappointing
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- Effects of a motilin receptor agonist (ABT-229) on upper gastrointestinal symptoms in type 1 diabetes mellitus: a randomised, double blind, placebo controlled trial
- N J Talley, M Verlinden, D J Geenen, R B Hogan, D Riff, R W McCallum, and R J Mack
Gut 2001 49: 395-401.[Abstract] [Full Text] [PDF]
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[Abstract] [Full Text]
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