Commentary
See article on page 364Beyond acid suppressants in gastro-oesophageal reflux disease
| The first 150 words of the full text of this article appear below. |
The burden of gastro-oesophageal reflux disease becomes apparent when one considers that treatment with acid suppressants accounts for a significant proportion of our national healthcare budget.1 Oh et al present evidence in this issue of Gut2 that a novel antioxidant substance (DA-9601) significantly attenuates the severity of oesophageal inflammation in a rat model of oesophagitis (see page 364). Furthermore, they demonstrated that DA-9601 was more effective in the prevention of oesophagitis than physiological concentrations of ranitidine.2
However, before we start prescribing antioxidants for
gastro-oesophageal reflux disease, several factors need to be
considered. Firstly, it is not clear why the authors chose to compare
antioxidants with H2 antagonists rather than with proton
pump inhibitors. Large randomised controlled trials of oesophagitis
suggest that whereas after eight weeks of treatment H2
antagonists achieve complete healing in up to 60% of patients, proton
pump inhibitors achieve endoscopically proved healing in approximately
90% of
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- Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats
- T Y Oh, J S Lee, B O Ahn, H Cho, W B Kim, Y B Kim, Y J Surh, S W Cho, K M Lee, and K B Hahm
Gut 2001 49: 364-371.[Abstract] [Full Text] [PDF]
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