Commentary
See article on page 488Counting the cost of proton pump inhibitors
| The first 150 words of the full text of this article appear below. |
Proton pump inhibitors (PPIs) have become an indispensable part of the armoury of treating gastro-oesophageal reflux disease (GORD). They are more effective than H2 receptor antagonists and prokinetic agents in oesophagitis and endoscopy negative reflux disease.1 This efficacy comes at a price however and PPIs are the most expensive class of drug in the UK, costing nearly £300 million in 1998.2 There have been attempts to curb PPI expenditure and the UK National Institute for Clinical Excellence has issued guidelines on appropriate prescription.2
The problem is that there is a dearth of health economic data to inform
those making health care decisions. Economic models have suggested that
PPIs are cost effective therapy for GORD but there have been criticisms
of this approach3 and they do not address the root of the
problem. Economic decisions are simple when a drug that is more
expensive and less effective is compared with a
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Gut 2001 49: 488-494.[Abstract] [Full Text] [PDF]
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