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Genomics at work: the global gene response to enteric bacteria
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The intestinal epithelium is the first point of contact for
prokaryotic organisms within the gut and plays a pivotal role in both
the recognition of microbial species and coordination of the host
response. Research on the molecular cross talk between pathogenic
organisms and intestinal epithelial cells has occupied centre stage for
many years, as gastroenterologists have actively dissected the major
signalling cascades, genes, and protein products that underpin
intestinal pathogenesis, with the aim of identifying potential
therapeutic targets. In recent years however there has been recognition
of the importance of the non-pathogenic (commensal) flora in gut
health. These organisms are intimately involved in driving the
development and maintenance of digestive and immunological functions of
the gut,1 2 but under predisposing conditions can also
trigger inflammatory bowel disease.3 The study of Hooper
et al is one of the first to utilise state
of the art molecular array technology and laser capture
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Mutch, D. M., Simmering, R., Donnicola, D., Fotopoulos, G., Holzwarth, J. A., Williamson, G., Corthesy-Theulaz, I.
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[Abstract] [Full Text]
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