Gut 2001;49:752-754 ( December )

Science alert

NOD2 (CARD15), the first susceptibility gene for Crohn's disease

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"This is not the end. It is not even the beginning of the end. But it is, perhaps, the end of the beginning." Sir Winston Churchill, 1942.

Comment

A "working model" of the pathophysiology of Crohn's disease (CD) is of an abnormal immune response to enteric bacteria in genetically susceptible individuals. There is a greater concordance for CD in monozygotic than dizygotic twins (concordance for CD in monozygotic twins 37% compared with 7% for dizygotic twins), suggesting a major genetic contribution to the pathogenesis of CD. The risk to siblings of affected individuals relative to the general population (s) is 15-40 for CD and the calculated heritability for CD is greater than that for schizophrenia or asthma and at least equal to that of type 1 diabetes.^1 2

Evidence for the role of enteric bacteria in the pathogenesis of CD comes from data demonstrating that genetically modified mice utilised . . . [Full text of this article]

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