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a Department of
Gastroenterology, Royal Berkshire Hospital, London Road, Reading
RG5 5AN, UK, b Institute
of Liver Studies, King's College London, Bessemer Road, London
SE5 9PJ, UK, c The Liver
and Hepatobiliary Unit, Queen Elizabeth Hospital, Birmingham B15
2TH, UK
Correspondence to: Dr J C L Booth.
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1.0 Guidelines |
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1.1 THE NEED FOR GUIDELINES
Hepatitis C virus (HCV) is a major health care concern in the UK
affecting some 200 000 to 400 000 individuals. The majority of these
patients will have chronic HCV infection and many will develop chronic
liver disease with the risk of developing cirrhosis and hepatocellular
carcinoma (HCC). Successful treatment will arrest the progression of
liver disease and so prevent the serious complications of chronic HCV
infection. In addition, treatment will reduce the numbers of HCV
infected individuals.
The relatively high cost of treatment enforces the need for a systematic approach for this condition so that resources are used most effectively. The development of clinical guidelines is important, as these will assist purchasing authorities, providers, clinicians, primary care groups, and patients in making decisions about appropriate treatment.
1.2 THE DEVELOPMENT OF GUIDELINES:
RIGOUR OF DEVELOPMENT/SYSTEMATIC CRITICAL REVIEW OF THE LITERATURE
1.2.1 Guideline development group
The development of
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