© 2002 by Gut
Digest
The sequential molecular changes that lead to colon cancer are being unravelled. The sequence of related histological changes is less well understood. Wong and colleagues have used microdissection techniques to isolate individual crypts from normal and neoplastic colonic mucosa. The authors (who include two Wongs and a Wright) have shown that, unlike normal mucosa, adenomas and hyperplastic polyps grow by crypt fission and their crypts are larger than normal. Furthermore, adenomas show cell proliferation up to the crypt surface indicating loss of control of the cell cycle. Interesting, buthistologists still seem to have some catching up to do in order to match the progress of molecular geneticists. See 212
|
|
Most clinical gastroenterologists will by now
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
Services
- Email this link to a friend
- Similar articles in this journal
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
