SCIENCE @LERT

Understanding selective trafficking of lymphocyte subsets

M Heydtmann, D H Adams

Liver Research Laboratories, MRC Centre for Immune Regulation, University of Birmingham Institute for Clinical Science, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH; email: d.h.adams@bham.ac.uk

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Bonzo/CXCR6 may be important in trafficking effector T cells making it a potential target for therapeutic modulation of inflammatory diseases

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Keywords: lymphocytes; Bonzo; inflammatory diseases

Cytokines produced by T (helper) cells are of critical importance in determining the outcome of many infectious and immune mediated diseases. The ability of the immune system to produce the appropriate set of cytokines in response to an infection and then to regulate that response as the infecting agent is cleared determines whether the response is successful and whether long term inflammatory damage persists. A crucial insight into how cytokines coordinate immune responses was provided by the characterisation of T cells into functional subsets¹: type 1 T cells, which are driven by interleukin 12, and dominated by interferon (IFN-) secretion and cell mediated immunity; and type 2 T cells, which are associated with interleukin 4 production and humoral immunity. Originally established on the basis of different cytokines produced by T helper (Th) cell clones, it is now clear that this concept defines distinct immune pathways that affect most, . . . [Full text of this article]

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