© 2002 by Gut
SCIENCE @LERT
The chips are down for Helicobacter pylori
Division of Gastroenterology and Institute of Infections and Immunity, University Hospital, Nottingham NG7 2UH, UK; John.Atherton@nottingham.ac.uk
Microarrays can be used to demonstrate differences in genetic content between Helicobacter pylori strains, giving a foretaste of how research may be conducted in the near future
Keywords: Helicobacter pylori; genetic content
The whole genome sequence of Helicobacter pylori strain 26695 was published in 1997 and that of a second strain, J99, in 1999.1, 2 These publications moved H pylori research forward by a quantum leap. Comparing H pylori genes with genes of known function in other bacteria gave immediate insights into H pylori metabolism, structure, adaptive mechanisms, and virulence. Research became more focused in that workers could identify and study genes that were known to be important in other bacteria and appreciate their whole genetic context in H pylori. For example, they could immediately see where an enzyme might fit in a metabolic pathway or what proteins were likely to comprise the H pylori flagella assembly. Now, several groups have taken another quantum leap forward. They have constructed whole genome microarrays—ordered arrays of all identified H pylori genes on glass slides—allowing experiments to be performed on all H pylori genes simultaneously.
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