Digest

Digest

Ian Forgacs, Associate Editor

At most international meetings these days, it is standing room only at the sessions on colonic microflora. Much of the current enthusiasm surrounds the interaction between bacteria and host mucosa. Yet bacteria-bacteria interactions themselves are of consuming interest. This month's Gut includes a paper on whether lactobacilli protect against cellular injury promoted by a pathogenic E coli strain. In the presence of lactobacilli there was a dose dependent decrease in E coli together with protection of brush border structure and function. Lactobacilli seem to have won the day. See page 803

Whatever else, sildenafil is an interesting drug. It blocks phosphodiesterase type 5 which degrades nitric oxide stimulated 3`5` cyclic GMP—resulting in smooth muscle relaxation. Studies in healthy males and patients with oesophageal motor over-reactivity showed a reduction of lower oesophageal sphincter pressure as well as diminished propulsion forces. These stimulating observations suggest a role for viagra in oesophageal dysmotility. . . . [Full text of this article]

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