COMMENTARY

Liver disease

HCC: What's the score

D Shouval

The Liver Unit, Hadassah University Hospital, Jerusalem, Israel

Correspondence to:
Correspondence to:
D Shouval, The Liver Unit, Hadassah University Hospital, Jerusalem, Israel;
Shouval@cc.huji.ac.il

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Choosing a scoring system for staging hepatocellular carcinoma is a difficult task

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Primary hepatocellular carcinoma (HCC) is a common neoplasm in East Asia, Africa, and the Mediterranean countries, with an age adjusted incidence rate of up to 20–28 cases per 10⁵ in men. Major progress has been made in the prevention of HCC through universal vaccination of neonates and children at risk worldwide, yet available treatment options for patients with established tumours rarely lead to complete cure. HCC is recognised for its heterogeneous clinical and biological presentation, variable natural course, and its relationship to defined risk factors and aetiologic agents, as well as the difficulty in predicting response to different modes of treatment. The time interval from an undetectable tumour to a 2 cm lesion may vary between four and 12 months which leaves a relatively narrow window for optimal intervention in already established tumours with a fast doubling time. In the past decade, a number of new palliative and . . . [Full text of this article]

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