COMMENTARY

Gut immunology

From hyperplasia to T cell lymphoma

N Cerf-Bensussan¹, N Brousse², C Cellier³

¹ INSERM EPI-9925, Faculté Necker-Enfants Malades, Paris, France
² INSERM EPI-9925, Faculté Necker-Enfants Malades, and Department of Pathology, Hôpital Necker-Enfants Malades, Paris, France
³ INSERM EPI-9925, Faculté Necker-Enfants Malades, and Department of Gastroenterology, Hôpital Européen Georges Pompidou, Paris, France

Correspondence to:
Correspondence to:
N Cerf-Bensussan, INSERM EPI-9925, Faculté Necker-Enfants Malades, 156 Rue de Vaugirard, 75737 Paris Cedex 15, France;
cerf@necker.fr.

---

Disturbances in intraepithelial lymphocyte homeostasis in coeliac disease may lead to the emergence of lymphoid malignancies

---

Keywords: refractory sprue; immunohistochemistry; intraepithelial lymphocytes; CD30; T cell lymphoma; enteropathy

The first 150 words of the full text of this article appear below.

Enteropathy-type intestinal T cell lymphomas (EITCL) are a recognised complication of coeliac disease (CD).¹ A recent survey confirmed that non-Hodgkin lymphomas, although rare, are the main cause of mortality in CD.² The mechanisms favouring the development of EITCL in CD patients but not in other chronic inflammatory bowel diseases remain elusive, but mounting evidence points to a profound disturbance in intraepithelial lymphocyte (IEL) homeostasis, leading to the emergence of lymphoid malignancies. A link between IELs and EITCL was first advocated in 1988 by Spencer et al who observed that most EITCL expressed the CD103 IEL marker.³ Two complementary observations suggested that EITCL derive from a reactive T cell population present in the intestine of CD patients: thus the same T cell clonal rearrangement was detected by Murray et al in EITCL and in the adjacent non-tumoral flat mucosa,⁴ and by Ashton-Key et al in non-lymphomatous ulcers of ulcerative . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Heterogeneity of intraepithelial lymphocytes in refractory sprue: potential implications of CD30 expression

I N Farstad, F-E Johansen, L Vlatkovic, J Jahnsen, H Scott, O Fausa, A Bjørneklett, P Brandtzaeg, and T S Halstensen
Gut 2002 51: 372-378. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

• Dickson, B C, Streutker, C J, Chetty, R (2006). Coeliac disease: an update for pathologists.. J. Clin. Pathol. 59: 1008-1016 [Abstract] [Full Text]  
• Verkarre, V, Asnafi, V, Lecomte, T, Mariaud-De Serre, N P., Leborgne, M, Grosdidier, E, Le Bihan, C, Macintyre, E, Cellier, C, Cerf-Bensussan, N, Brousse, N (2003). Refractory coeliac sprue is a diffuse gastrointestinal disease. Gut 52: 205-211 [Abstract] [Full Text]