© 2002 by Gut
Digest
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The natural history of acute pancreatitis is particularly fascinatingespecially given the spectrum of the condition from mild inflammation to massive haemorrhagic necrosis. Zimmerman and colleagues have been interested in the regenerative process after necrotising pancreatitis, and studied surgical specimens to determine the key cells involved. They showed that regeneration was quite ordered. The process involved pancreatic stellate cells and their myofibroblast offspring. Although stellate cells are closely involved in pancreatic fibrosis, this study helps to clarify their role in acute severe injury.
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The general reader of this journal may not be well versed in gastrointestinal electrophysiology. One must hope that a real breakthrough in motility cannot be all that far awayafter all, disturbances of motility cause so much distress to our patients and effective therapy is so limited. Lyford and colleagues highlight the importance of the interstitial cells of Cajal (JCC) as the intestinal pacemaker. An elegant
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