COMMENTARY

Cancer

Risk of pancreatic ductal adenocarcinoma in chronic pancreatitis

N Howes, J P Neoptolemos

Department of Surgery, University of Liverpool, Liverpool, UK

Correspondence to:
Correspondence to:
Professor J P Neoptolemos, Department of Surgery, 5th Floor UCD Building, Daulby Street, Liverpool L69 3GA, UK;
j.p.neoptolemos@liverpool.ac.uk

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Patients with chronic pancreatitis have a markedly increased risk of pancreatic cancer compared with the general population

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Keywords: chronic pancreatitis; pancreatic adenocarcinoma

The first 150 words of the full text of this article appear below.

Chronic pancreatitis has been proposed as an independent risk factor for the development of pancreatic cancer in a number of important studies.^1–3 Problems with methodology however, such as patient selection, ascertainment bias, small patient numbers, and stringency of patient selection have been major criticisms, leading some authors to believe that the risk of pancreatic cancer in chronic pancreatitis is confounded by other risk factors such as smoking.⁴ The study presented by Malka and colleagues⁵ in this issue of Gut has addressed some of these considerations, in that it has prospectively followed a cohort of 373 patients with proven chronic pancreatitis, defined by stringent criteria, over a median of 9.2 years [see page 849]. The high incidence of pancreatic calcification (83%), elective surgery (60%), diabetes mellitus (54%), pseudocysts (46%), and venous occlusive disease (21%) leave little room for doubt that this is a true cohort of patients with . . . [Full text of this article]

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This article has been cited by other articles:

• Ghaneh, P, Costello, E, Neoptolemos, J P (2008). Biology and management of pancreatic cancer. Postgrad. Med. J. 84: 478-497 [Full Text]  
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