© 2002 by Gut
SCIENCE @LERT
The NF
B luciferase mouse: a new tool for real time measurement of NFB activation in the whole animal
Liver Research Group, University of Southampton, Southampton, UK; dam2@soton.ac.uk
Development of transgenic mice that express luciferase under the control of nuclear factor
B (NFB) enables real time in vivo imaging of NFB activity in intact animals
Keywords: nuclear factor B; luciferase mouse
| The first 150 words of the full text of this article appear below. |
Of the many different transcription factors found in mammalian cells by far the best known among scientists and clinicians alike is nuclear factor B (NFB). In addition to its pivotal role as a regulator of innate and adaptive immune responses, NFB has also been linked as a contributory factor in many human disorders.1 NFB stimulates transcription of over 150 different genes encoding cytokines, adhesion molecules, immunoreceptors, acute phase proteins, enzymes, and regulators of the cell cycle and apoptosis.2 Transcription of these genes is stimulated in response to binding of NFB to a specific 10 base pair DNA sequence (GGGRNNYYCC, where R corresponds to a purine, Y represents a pyrimidine, and N can be any base) located in either the enhancer or upstream promoter regions of a gene. Binding of NFB to these sequences is tightly regulated by the inhibitory function of the IB-
protein
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Gut 2002 51: 759.[Extract] [Full Text] [PDF]
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